Microplastics
Bioresponse to microplastics
Microplastics are increasingly detected in various environmental compartments and have also been found in human tissues, raising concerns about potential health implications. While the exact effects on human health remain under investigation, early studies suggest possible links to inflammation or interference with cellular processes. Ongoing research is essential to better understand exposure pathways, dose thresholds, and long-term biological responses. Based on our previous experience in investigating polymer micro-/nanoparticles with respect to protein adsorption and cellular recognition, we aim to contribute to this important field.
Exemplary own publications related to protein adsorption and cellular uptake of submicron particles and related model analytical studies are:
S. Baudis, T. Roch, M. Balk, C. Wischke, A. Lendlein, M. Behl. Multivariate Analysis of Cellular Uptake Characteristics for a (Co)polymer Particle Library, ACS Biomater. Sci. Eng. 2024, 10, 3, 1481–1493; https://doi.org/10.1021/acsbiomaterials.3c01803
B. Seifert, S. Baudis, C. Wischke. Composition-Dependent Protein–Material Interaction of Poly(Methyl Methacrylate-co-styrene) Nanoparticle Series, International Journal of Molecular Sciences 2023, 24(22), 16390; https://doi.org/10.3390/ijms242216390
N. Zhang, A. Said, C. Wischke, V. Kral, R. Brodwolf, P. Volz, A. Boreham, C. Gerecke, W. Li, A. T. Neffe, B. Kleuser, U. Alexiev, A. Lendlein, M. Schäfer-Korting, Poly[acrylonitrile-co-(N-vinyl pyrrolidone)] nanoparticles - composition-dependent skin penetration enhancement of a dye probe and biocompatibility, Eur J Pharm Biopharm, 116 (2017), 66-75. http://dx.doi.org/10.1016/j.ejpb.2016.10.019
S. Staufenbiel, M. Merino, W. Li, M.-D. Huang, S. Baudis, A. Lendlein, R.H. Müller, C. Wischke, Surface characterization and protein interaction of a series of model poly[acrylonitrile-co-(N-vinyl pyrrolidone)] nanocarriers for drug targeting, Int J Pharm, 485,(2015), 87-96. http://dx.doi.org/10.1016/j.ijpharm.2015.02.072
Q. Wei, T. Becherer, S. Angioletti-Uberti, J. Dzubiella, C. Wischke, A.T. Neffe, A. Lendlein, M. Ballauff, R. Haag, Protein Interactions with Polymer Coatings and Biomaterials, Angew Chem Int Ed, 53 (2014), 8004-8031. German Version available as: Angew Chem, 126 (2014), 8138-8169. http://dx.doi.org/10.1002/anie.201400546
C. Wischke, A. Kruger, T. Roch, B.F. Pierce, W. Li, F. Jung, A. Lendlein, Endothelial cell response to (co)polymer nanoparticles depending on the inflammatory environment and comonomer ratio, Eur J Pharm Biopharm, 84 (2013), 288-296. https://pubmed.ncbi.nlm.nih.gov/23429231/