Forschungsaktivitäten
Strategies to overcome age-related immunosenescence
Immunosenescence is the state of deteriorated immune response to pathogens, associated with the elevated release of inflammatory markers and vulnerability to diseases such as autoimmune disorders and cancer. Drug delivery systems (DDS) provide versatile benefits for treating age-linked diseases, including improved efficacy, cell- or organ-specific transportation, increased absorption, reduced side effects, and controlled drug release...
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Bioresponse to microplastics
Microplastics are increasingly detected in various environmental compartments and have also been found in human tissues, raising concerns about potential health implications. While the exact effects on human health remain under investigation, early studies suggest possible links to inflammation or interference with cellular processes. Ongoing research is essential to better understand exposure pathways, dose thresholds, and long-term biological responses...
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Sustainable microparticulate drug delivery systems and particle modification
Polymeric microparticles are injectable carrier systems that enable localized drug administration directly into tissue, allowing a drug payload to be slowly released to mediate either local or systemic biological effects. The preparation of such particles can be performed by traditional batch emulsification or more advanced techniques, including droplet-based microfluidics. We apply our expertise in designing and constructing microfluidic setups using glass capillaries as well as through soft lithography...
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Switchable carriers for medical intervention
Switchable drug carriers can be created using polymers, which undergo structural changes either at the chemical (molecular) level or in their polymer morphology in response to specific triggers. In a number of projects, we are exploring the extent to which this type of response can be controlled and transferred to a pharmaceutical context – for example, through alterations of particle dimensions or on-demand release...
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Long-term implants for local release
Research on long-term biomedical implants for local drug release focusses on the treatment of anatomical compartments that are poorly accessible via systemic administration. In such enclosed or isolated sites, achieving therapeutic concentrations through the bloodstream is often ineffective or may be associated with systemic side effects. Examples of such compartments include different segments of the eye or bone cavities—areas where physiological barriers limit drug penetration from the bloodstream...
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3D-printed and hybrid-material implant systems
The combination of different materials enables the creation of hybrid drug delivery systems that integrate complementary properties, such as mechanical strength, degradability, and release kinetics. Engineering concepts like 3D printing play a key role in fabricating such systems, as they allow precise spatial control and the integration of multiple materials within a single device. This technology also supports the design of complex architectures, including gradient and hybrid structures tailored to specific therapeutic needs...
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Characterization of materials and drug carrier systems
Characterization of materials and drug carriers on different hierarchical levels—from molecular composition to macroscopic structure—is essential for understanding their functional performance. Each level of organization influences key properties such as drug loading capacity, release kinetics, mechanical stability, and biocompatibility. Comprehensive, multi-scale analysis enables rational design and optimization of carriers tailored to specific therapeutic applications...
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Polyester-based particles as drug carriers
Polyester-based particles as drug carriers
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