Martin Luther University Halle-Wittenberg

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Paola Modicano

Pharmaceutical Technology and Biopharmaceutics
Biopharmacy group

Room 419.1
Kurt-Mothes-Straße 3
06120 Halle (Saale)

Telephone: +49 (0) 345 55-25214
E-mail:

ORCID: https://orcid.org/0000-0002-0914-6503   

Research Projects

Development and characterization of photoluminescent conjugated polymer nanoparticles for bioimaging applications and investigation of their phototoxic effect

Curriculum vitae

since 01.2021 - VIARES Ambassador: https://theviares.com/?ambassador=9   

since 08. 2016 - PhD student in the working group of Prof. Lea Ann Dailey

04.2015 - 09.2015 - Traineeship - Erasmus + program
Martin- Luther- Universität  Halle- Wittenberg. Institute of Pharmacy - Pharmaceutical Technology  Group, Halle (Saale), Germany. Supervisor: Prof. Dr. rer. nat. habil.  Karsten Mäder. Project: manufacturing of nano-sized formulation by different mixing and dispersion methods

03.2013 - 08.2013 - Traineeship - LLP Erasmus Placement
Eberhard-Karls-University of Tuebingen, Department of Physiology, Germany. Supervisor: Prof. Dr. med. Dr.h.c. Florian Lang, Tübingen (Germany). Project: Study of the physiological mechanisms underlying eryptosis, i.e. the suicidal death of erythrocytes

10.2012 - 12.2016 - Master studies in Biology. University of Messina, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Messina (Italy). Thesis in Pathophysiology: "Effect of thioridazine on erythrocytes". Supervisor: Prof. Caterina Faggio and Prof. Dr. med. Dr.h.c. Florian Lang

12.2005 - 07.2012 - Bachelor studies in Biological Sciences. University of Messina, Department of Biological and Environmental Sciences, Messina (Italy). Thesis in Physiology: "Ca2+signaling in the regulation of dendritic cell functions". Supervisor: Prof.Caterina Faggio

Publications

Enhanced optical imaging properties of lipid nanocapsules as vehicles for fluorescent conjugated polymers. European Journal of Pharmaceutics and Biopharmaceutics, 2020. DOI: 10.1016/j.ejpb.2020.07.017   

Effect of saponin on erythrocytes. Int J Hematol, 2014. DOI: 10.1007/s12185-014-1605-z   

Stimulation of Erythrocyte Cell Membrane Scrambling by Mitotane. Cell Physiol Biochem., 2014. DOI: 10.1159/000358715   

Estramustine induced suicidal erythrocyte death. Cell Physiol Biochem, 2013. DOI: 10.1159/000356580   

Effect of nitazoxanide on erythrocytes. Basic Clin Pharmacol Toxicol., 2013. DOI: 10.1111/bcpt.12171   

Effect of thioridazine on erythrocytes.Toxins, 2013. DOI: 10.3390/toxins5101918   

Conference contributions

Paola Modicano, Karsten Mäder, Lea Ann Dailey. Enhanced performance of lipid nanocapsule formulations of NIR-emitting conjugated polymers for optical and photoacoustic imaging. PBP World Meeting, 2021, Vienna, Austria - (ORAL PRESENTATION).

Paola Modicano, Lea Ann Dailey. Characterisation of conjugated polymer-loaded lipid nanocapsules. BioNanoMed, 2019, Graz, Austria - (POSTER).

Paola Modicano, Lea Ann Dailey. Conjugated polymer-loaded lipid nanocapsules: a promising andstable fluorescent NIR probe? Controlled Release Society Local Chapter Meeting, 2019, Leipzig, Germany - (POSTER).

Paola Modicano, Lea Ann Dailey. Are lipid nanocapsules a suitable carrier system for fluorescent conjugated polymers? Controlled Release Society Local Chapter Meeting, 2018, Halle, Germany - (POSTER).

Paola Modicano, Ewelina Hoffman, Ben Forbes, Lea Ann Dailey. Foamy macrophage phenotype: physiological adaptive response or pathological adverse event to inhaled medicines? 89th SIBS National Congress, 2016, At Ozzano dell’Emilia (BO), Italy - (ORAL PRESENTATION).

Paola Modicano, Karsten Mäder, Caterina Faggio. Preparation of blank and F8BT-loaded lipid nanocapsiles based on a phase inversion method and their preliminary charcaterization. 88th SIBS Conference - Italian Society of Experimental Biology, 2015, Genoa, Italy - (ORAL PRESENTATION).

Paola Modicano and Caterina Faggio. Lipid nanocapsules as promising carriers for Drug Delivery System with a Trojan horse strategy. 88th SIBS Conference - Italian Society of Experimental Biology, 2015, Genoa, Italy - (POSTER).

Modicano P., Bissinger R., Alzoubi K., Honisch S., Abed M., Lang F., Faggio C. Saponin, a trigger of eryptosis, the suicidal erythrocyte death. 87th SIBS National Congress on People, Environment, Health, 2014, Turin, Italy - (POSTER).

Modicano P., Arnold M., Lang E., Bissinger R., Abed M., Lang F., Faggio C. Stimulation of suicidal erythrocyte death by nitazoxanide. 87th SIBS National Congress on People, Environment, Health, 2014, Turin, Italy - (POSTER).

Modicano P., Jacobi J., Lang E., Bissinger R., Frauenfeld L., Faggio C., Abed M., Lang F.  Stimulation of erythrocyte cell membrane scrambling by mitotane. 93rd Annual Meeting of the German Physiological Society (DPG), 2014, Mainz, Germany - (POSTER).

Bissinger R., Modicano P., Frauenfeld L., Lang E., Jacobi J., Faggio C., Lang F. Estramustine-induced suicidal erythrocyte death. 93rd Annual Meeting of the GermanPhysiological Society (DPG), 2014, Mainz, Germany - (POSTER).

Modicano P., Lang E., Arnold M., Bissinger R., Faggio C., Abed M., Lang F. Effect of thioridazine on erythrocytes. 86° SIBS National Congress, 2013, Palermo, Italy - (POSTER).

Teaching

Supervision of the following practical courses :

  • Preparation of suppositories  (AFL I)
  • Semi-solid dosage form (AFL II)

Awards & achievements

  • Frauenförderung 2020: Netzwerkmitte
  • 2015 - Stipendium: ERASMUS+ Stipendium für einen Forschungsaufenthalt am Institut für Pharmazie der Martin-Luther-Universität Halle-Wittenberg · Bereich Pharmazeutische Technologie und Biopharmazie · AG Pharmazeutische Technologie
  • 2012 - Stipendium: LLP ERASMUS Placement Stipendium für ein Forschungspraktikum am Institut für Physiologie, Universität Tübingen, Deutschland

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